| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Sao Paulo, Proc Control & Simulat Lab, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Publ Hlth, BR-01246904 Sao Paulo - Brazil
Total Affiliations: 2
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| Document type: | Journal article |
| Source: | Journal of Theoretical Biology; v. 335, p. 57-78, OCT 21 2013. |
| Web of Science Citations: | 6 |
| Abstract | |
In this paper, we sought to identify the CD4(+) T-cell dynamics in the course of HIV infection in response to continuous and intermittent intravenous courses of interleukin-2 (IL-2), the principal cytokine responsible for progression of CD4(+) T-lymphocytes from the Cl to the S phase of the cell cycle. Based on multivariate regression models, previous literature has concluded that the increase in survival of CD4(+) T-cell appears to be the critical mechanism leading to sustained CD4(+) T-cell levels in HIV-infected patients receiving intermittent IL-2 therapy. Underscored by comprehensive mathematical modeling, a major finding of the present work is related to the fact that, rather than due to any increase in survival of CD4(+) T-cells, the expressive, selective and sustained CD4(+) T-cell expansions following IL-2 administration may be related to the role of IL-2 in modulating the dynamics of Fas-dependent apoptotic pathways, such as activation-induced cell death (AICD) or HIV-specific apoptotic routes triggered by viral proteins. (C) 2013 Elsevier Ltd. All rights reserved. (AU) | |