Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma

Autor(es)

Campos, Antonio Hugo ^[1] ; Vassallo, Jose ^{[1, 2]} ; Soares, Fernando Augusto ^[1]

Afiliação do(s) autor(es)

^[1] AC Camargo Canc Care Ctr, Dept Anat Pathol, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Lab Invest & Mol Pathol CIPED, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 8, n. 9 SEP 24 2013.
• Citações Web of Science: 3

Resumo

Previous studies have investigated the prognostic relevance of MMP9 in classical Hodgkin lymphoma (cHL), with negative results. However, we have found that MMP9 immunoistochemical expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in a subset of young adult Brazilian patients diagnosed with cHL. Additionally, we have observed that MMP9 expression by neoplastic cells in cHL is associated with EBV positivity. These results may support a rational basis for additional studies on the role of this metalloproteinase as a target for therapy in classical Hodgkin lymphoma. (AU)

• Processo FAPESP: 06/02183-1 - Análise do perfil de expressão gênica em amostras de linfoma de Hodgkin clássico: estudo da patogênese com ênfase no papel da infecção pelo vírus de Epstein-Barr
• Beneficiário: Fernando Augusto Soares
• Modalidade de apoio: Auxílio à Pesquisa - Regular