Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma

Campos, Antonio Hugo; Vassallo, Jose; Soares, Fernando Augusto

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma

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Author(s):	Campos, Antonio Hugo ^[1] ; Vassallo, Jose ^{[1, 2]} ; Soares, Fernando Augusto ^[1] Total Authors: 3
Affiliation:	^[1] AC Camargo Canc Care Ctr, Dept Anat Pathol, Sao Paulo - Brazil ^[2] Univ Estadual Campinas, Fac Med Sci, Lab Invest & Mol Pathol CIPED, Campinas, SP - Brazil Total Affiliations: 2
Document type:	Journal article
Source:	PLoS One; v. 8, n. 9 SEP 24 2013.
Web of Science Citations:	3
Abstract
Previous studies have investigated the prognostic relevance of MMP9 in classical Hodgkin lymphoma (cHL), with negative results. However, we have found that MMP9 immunoistochemical expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in a subset of young adult Brazilian patients diagnosed with cHL. Additionally, we have observed that MMP9 expression by neoplastic cells in cHL is associated with EBV positivity. These results may support a rational basis for additional studies on the role of this metalloproteinase as a target for therapy in classical Hodgkin lymphoma. (AU)

FAPESP's process:	06/02183-1 - Gene expression analysis in classical Hodgkin lymphoma: a pathogenetic study emphasizing the role of Epstein-Barr virus infection
Grantee:	Fernando Augusto Soares
Support Opportunities:	Regular Research Grants

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