| Grant number: | 14/24894-3 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | May 01, 2015 |
| End date: | December 31, 2015 |
| Field of knowledge: | Biological Sciences - Genetics - Human and Medical Genetics |
| Principal Investigator: | Gustavo Jacob Lourenço |
| Grantee: | Bruna de Albuquerque Murbach |
| Host Institution: | Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract The dependency and prognosis of the Hodgkin lymphoma (HL) on angiogenesis (AG), characterized by overexpression of the vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR2) was described recently. However, distinct inherited abilities for AG, associated with genetic polymorphisms, may influence the VEGF production and the potential of VEGF ligation to VEGFR2. Thus, the objective of this study is the evaluate the roles of the polymorphisms c.-2055A>G (rs699947) and c.-614A>G (rs1570360) of the VEGF gene and c.-906T>C (rs2071559) and c.889G>A (rs2305948) of the VEGFR2 gene in the classical HL (cHL) occurrence and in clinical characteristics and survival. It will be evaluated 120 patients with cHL and 120 controls, matched to patients by age, gender and skin color, treated at the Hematology and Hemotherapy Center of University of Campinas. The clinical information will be obtained in the patients' record by the researcher. The genotypes of the referred polymorphisms will be identified by real time polymerase chain reaction, using TaqMan® assays. The statistical significance of the difference between groups will be calculated by Fischer's exact test or Ç2, and multiple logistic regressions. The cHL risk determination will be calculated by odds ratio considering a 95% confidence interval. The disease free survival and overall survival times will be calculated using Kaplan-Meier estimate probabilities and differences between survival curves will be analyzed by the log-rank test. The prognostic impact of genotypes will be examined using univariate and multivariate Cox regression analyses. We believe that the results of this study could contribute to knowledge of the etiology and physiopathology of the cHL, and these results also could identify individuals with higher risk to disease and receive special attention to prevention, early disease diagnosis and treatment. | |
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