Modafinil ameliorates cognitive deficits induced by maternal separation and sleep deprivation

Autor(es)

Garcia, Vanessa Athaide ^{[1, 2, 3]} ; Hirotsu, Camila ^[1] ; Matos, Gabriela ^[1] ; Alvarenga, Tathiana ^[1] ; Pires, Gabriel Natan ^[1] ; Kapczinski, Flavio ^{[2, 4, 5]} ; Schroeder, Nadja ^{[2, 3]} ; Tufik, Sergio ^[1] ; Andersen, Monica Levy ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil

^[2] Natl Inst Translat Med INCT TM, BR-90035003 Porto Alegre, RS - Brazil

^[3] Pontifical Catholic Univ, Fac Biosci, Neurobiol & Dev Biol Lab, BR-90619900 Porto Alegre, RS - Brazil

^[4] Univ Fed Rio Grande do Sul, Bipolar Disorders Program, BR-90035003 Porto Alegre, RS - Brazil

^[5] Univ Fed Rio Grande do Sul, Lab Mol Psychiat, BR-90035003 Porto Alegre, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 253, p. 274-279, SEP 15 2013.
• Citações Web of Science: 14

Resumo

Animals exposed to an early adverse event may be more susceptible to a second source of stress later in life, and these stressors may have additive deleterious effects. Sleep deprivation is known to be a stressor, affecting multiple body functions such as the cognition. Modafinil enhances working memory and attention in healthy non-sleep deprived subjects and in animal models of sleep deprivation. The first aim of the present study was to investigate the effects of maternal separation (MS) combined with paradoxical sleep deprivation (PSD) in adulthood on recognition memory in rats. Second, we aimed to evaluate whether the administration of modafinil would be able to ameliorate memory deficits induced by MS and PSD. Wistar rat pups were initially distributed into MS and handling (H) groups, with their litters standardized in 4 females and 4 males. In adulthood, the male rats were submitted to PSD or control condition, being redistributed afterwards in modafinil- or vehicle-treatment immediately after the training session of object recognition task. PSD did not potentiate the cognitive deficit due to MS. However, modafinil was able to recover memory impairments associated to PSD and also to MS in the neonatal period. This study demonstrates for the first time that modafinil ameliorates cognitive deficits associated to MS and to PSD in adulthood, independent from MS in the neonatal period. (C) 2013 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/12325-6 - Efeitos da privação de sono e da síndrome da apnéia obstrutiva do sono na função reprodutiva em homens
• Beneficiário: Tathiana Aparecida Fernandes de Alvarenga
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/05396-7 - Efeitos no desenvolvimento sensorial e sexual da prole de ratas submetidas à restrição de sono
• Beneficiário: Monica Levy Andersen
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/15110-8 - Sono e morte súbita nas epilepsias: provável base molecular?
• Beneficiário: Gabriela de Matos Barbosa Pimenta
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 10/50129-1 - Insuficiência renal crônica, restrição de sono e sildenafil: consequências renais, cardíacas e sexuais em um modelo animal
• Beneficiário: Camila Hirotsu
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto