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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance

Texto completo
Autor(es):
Rodrigues Danzi Salvia, Ana Carolina [1] ; Figueiredo, Maria Stella [2] ; Pellegrini Braga, Josefina Aparecida [2] ; Alves Pereira, Daniel Freitas [1] ; Brighenti, Fernanda Lourencao [1] ; Koga-Ito, C. Y. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Sao Jose Dos Campos - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 42, n. 7, p. 570-575, AUG 2013.
Citações Web of Science: 1
Resumo

BackgroundThe aim of this study was to evaluate the frequency of Candida species and presence of lesions in the oral cavity of patients with sickle cell anemia (SS). MethodsThe study included 30 patients diagnosed with sickle cell anemia and taking hydroxyurea for at least 90days (SS/HU+); and 39 patients with sickle cell anemia and without hydroxyurea therapy (SS/HU-). Two control groups were constituted by healthy individuals matched to the test groups in age, gender, and oral conditions (C/HU+ for SS/HU+ and C/HU- for SS/HU-). Oral clinical examination and anamnesis were performed. Yeasts were collected by oral rinses and identified by API system. Antifungal susceptibility evaluation was performed according to the CLSI methodology. Data obtained for microorganisms counts were compared by Student's t test (SS/HU+ vs. C/HU+ and SS/HU- vs. C/HU-) using MINITAB for Windows 1.4. Significance level was set at 5%. ResultsNo oral candidosis lesions were detected. Significant differences in yeasts counts were observed between SS/HU- group and the respective control, but there were no differences between SS/HU+ and C/HU+. Candida albicans was the most prevalent species in all groups. Candida famata was observed both in SS and control groups. Candida dubliniensis, Candida glabrata, Candida krusei, Candida tropicalis, Candida pelliculosa, and Candida parapsilosis were observed only in SS groups. Most strains were susceptible to all antifungal agents. ConclusionHydroxyurea therapy seems to decrease candidal counts and resistance rate in sickle cell anemia patients. However, further studies should be conducted in the future to confirm this finding. Hydroxyurea therapy in sickle cell anemia patients maintains fungal species balance in oral cavity. (AU)

Processo FAPESP: 08/56484-8 - Presença de microrganismos potencialmente superinfectantes na cavidade bucal de pacientes com anemia falciforme em uso de hidroxiuréia
Beneficiário:Ana Carolina Rodrigues Danzi Salvia
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 09/50028-3 - Presença e sensibilidade aos antimicrobianos de microorganismos potencialmente superinfectantes na cavidade bucal de pacientes com anemia falciforme em uso de hidroiureia
Beneficiário:Cristiane Yumi Koga Ito
Linha de fomento: Auxílio à Pesquisa - Regular