Hydroxyurea therapy in sickle cell anemia patients aids to maintain oral fungal colonization balance

Autor(es)

Rodrigues Danzi Salvia, Ana Carolina ^[1] ; Figueiredo, Maria Stella ^[2] ; Pellegrini Braga, Josefina Aparecida ^[2] ; Alves Pereira, Daniel Freitas ^[1] ; Brighenti, Fernanda Lourencao ^[1] ; Koga-Ito, C. Y. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Sao Jose Dos Campos - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 42, n. 7, p. 570-575, AUG 2013.
• Citações Web of Science: 1

Resumo

BackgroundThe aim of this study was to evaluate the frequency of Candida species and presence of lesions in the oral cavity of patients with sickle cell anemia (SS). MethodsThe study included 30 patients diagnosed with sickle cell anemia and taking hydroxyurea for at least 90days (SS/HU+); and 39 patients with sickle cell anemia and without hydroxyurea therapy (SS/HU-). Two control groups were constituted by healthy individuals matched to the test groups in age, gender, and oral conditions (C/HU+ for SS/HU+ and C/HU- for SS/HU-). Oral clinical examination and anamnesis were performed. Yeasts were collected by oral rinses and identified by API system. Antifungal susceptibility evaluation was performed according to the CLSI methodology. Data obtained for microorganisms counts were compared by Student's t test (SS/HU+ vs. C/HU+ and SS/HU- vs. C/HU-) using MINITAB for Windows 1.4. Significance level was set at 5%. ResultsNo oral candidosis lesions were detected. Significant differences in yeasts counts were observed between SS/HU- group and the respective control, but there were no differences between SS/HU+ and C/HU+. Candida albicans was the most prevalent species in all groups. Candida famata was observed both in SS and control groups. Candida dubliniensis, Candida glabrata, Candida krusei, Candida tropicalis, Candida pelliculosa, and Candida parapsilosis were observed only in SS groups. Most strains were susceptible to all antifungal agents. ConclusionHydroxyurea therapy seems to decrease candidal counts and resistance rate in sickle cell anemia patients. However, further studies should be conducted in the future to confirm this finding. Hydroxyurea therapy in sickle cell anemia patients maintains fungal species balance in oral cavity. (AU)

• Processo FAPESP: 08/56484-8 - Presenca de microrganismos potencialmente superinfectantes na cavidade bucal de pacientes com anemia falciforme em uso de hidroxiureia
• Beneficiário: Ana Carolina Rodrigues Danzi Salvia
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 09/50028-3 - Presença e sensibilidade aos antimicrobianos de microorganismos potencialmente superinfectantes na cavidade bucal de pacientes com anemia falciforme em uso de hidroxiureia
• Beneficiário: Cristiane Yumi Koga Ito
• Modalidade de apoio: Auxílio à Pesquisa - Regular