Inflammation, Myocardial Dysfunction, and Mortality in Children With Septic Shock: An Observational Study

Autor(es)

Carmona, Fabio ^[1] ; Manso, Paulo H. ^[1] ; Silveira, Vanessa S. ^[1] ; Cunha, Fernando Q. ^[1] ; de Castro, Margaret ^[1] ; Carlotti, Ana P. C. P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PEDIATRIC CARDIOLOGY; v. 35, n. 3, p. 463-470, MAR 2014.
• Citações Web of Science: 3

Resumo

We aimed to investigate whether nuclear factor kappa-B activation, as evaluated by gene expression of its inhibitor (I-kappa B alpha) and cytokine serum levels, was associated with myocardial dysfunction and mortality in children with septic shock. Twenty children with septic shock were prospectively enrolled and grouped according to ejection fraction (EF) < 45 % (group 1) or EF a parts per thousand yen45 % (group 2) on the first day after admission to the pediatric intensive care unit. No interventions were made. In the first day, patients from group 1 (n = 6) exhibited significantly greater tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-10 plasma levels. However, I-kappa B alpha gene expression was not different in both groups. Mortality and number of complications were significantly greater in group 1. Patients who died had greater plasma concentrations of TNF-alpha. In conclusion, TNF-alpha and IL-10 are involved in myocardial dysfunction accompanying septic shock in children, and TNF-alpha is associated with mortality. (AU)

• Processo FAPESP: 04/01441-1 - Avaliacao da concentracao serica pos-operatoria de citocinas pro e anti-inflamatorias e da troponina i cardiaca em criancas submetidas a circulacao extracorporea.
• Beneficiário: Ana Paula de Carvalho Panzeri Carlotti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/05067-8 - Avaliação do uso do pré-condicionamento isquêmico remoto no dia precedente à cirurgia em crianças submetidas à circulação extracorpórea (efeitos na segunda janela)
• Beneficiário: Ana Paula de Carvalho Panzeri Carlotti
• Modalidade de apoio: Auxílio à Pesquisa - Regular