Inflammation, Myocardial Dysfunction, and Mortality in Children With Septic Shock: An Observational Study

Author(s)

Carmona, Fabio ^[1] ; Manso, Paulo H. ^[1] ; Silveira, Vanessa S. ^[1] ; Cunha, Fernando Q. ^[1] ; de Castro, Margaret ^[1] ; Carlotti, Ana P. C. P. ^[1]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: PEDIATRIC CARDIOLOGY; v. 35, n. 3, p. 463-470, MAR 2014.
• Web of Science Citations: 3

Abstract

We aimed to investigate whether nuclear factor kappa-B activation, as evaluated by gene expression of its inhibitor (I-kappa B alpha) and cytokine serum levels, was associated with myocardial dysfunction and mortality in children with septic shock. Twenty children with septic shock were prospectively enrolled and grouped according to ejection fraction (EF) < 45 % (group 1) or EF a parts per thousand yen45 % (group 2) on the first day after admission to the pediatric intensive care unit. No interventions were made. In the first day, patients from group 1 (n = 6) exhibited significantly greater tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-10 plasma levels. However, I-kappa B alpha gene expression was not different in both groups. Mortality and number of complications were significantly greater in group 1. Patients who died had greater plasma concentrations of TNF-alpha. In conclusion, TNF-alpha and IL-10 are involved in myocardial dysfunction accompanying septic shock in children, and TNF-alpha is associated with mortality. (AU)

• FAPESP's process: 08/05067-8 - Assessment of the use of remote ischemic preconditioning on the day before surgery in children undergoing cardiopulmonary bypass (second window effects)
• Grantee: Ana Paula de Carvalho Panzeri Carlotti
• Support Opportunities: Regular Research Grants