Memory Networks in Tinnitus: A Functional Brain Image Study

Autor(es):Mostrar menos -

Laureano, Maura Regina ^[1] ; Onishi, Ektor Tsuneo ^[2] ; Bressan, Rodrigo Affonseca ^{[3, 1]} ; Vieira Castiglioni, Mario Luiz ^[4] ; Batista, Ilza Rosa ^{[3, 1]} ; Reis, Marilia Alves ^{[3, 1]} ; Garcia, Michele Vargas ^[5] ; de Andrade, Adriana Neves ^[5] ; de Almeida, Roberta Ribeiro ^[1] ; Garrido, Griselda J. ^[6] ; Jackowski, Andrea Parolin ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psiquiatria, LiNC, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Otorrinolaringol & Cirurgia Cabeca & Pescoco, Sao Paulo - Brazil

^[3] Hosp Israelita Albert Einstein, Inst Cerebro, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Radiol, Secao Med Nucl, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Fonoaudiol, Sao Paulo - Brazil

^[6] Univ Western Australia, Med Res Ctr, Western Australian Ctr Hlth & Ageing, Perth, WA 6009 - Australia

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 9, n. 2 FEB 6 2014.
• Citações Web of Science: 15

Resumo

Tinnitus is characterized by the perception of sound in the absence of an external auditory stimulus. The network connectivity of auditory and non-auditory brain structures associated with emotion, memory and attention are functionally altered in debilitating tinnitus. Current studies suggest that tinnitus results from neuroplastic changes in the frontal and limbic temporal regions. The objective of this study was to use Single-Photon Emission Computed Tomography (SPECT) to evaluate changes in the cerebral blood flow in tinnitus patients with normal hearing compared with healthy controls. Methods: Twenty tinnitus patients with normal hearing and 17 healthy controls, matched for sex, age and years of education, were subjected to Single Photon Emission Computed Tomography using the radiotracer ethylenedicysteine diethyl ester, labeled with Technetium 99 m (99 mTc-ECD SPECT). The severity of tinnitus was assessed using the ``Tinnitus Handicap Inventory{''} (THI). The images were processed and analyzed using ``Statistical Parametric Mapping{''} (SPM8). Results: A significant increase in cerebral perfusion in the left parahippocampal gyrus (pFWE<0.05) was observed in patients with tinnitus compared with healthy controls. The average total THI score was 50.8+18.24, classified as moderate tinnitus. Conclusion: It was possible to identify significant changes in the limbic system of the brain perfusion in tinnitus patients with normal hearing, suggesting that central mechanisms, not specific to the auditory pathway, are involved in the pathophysiology of symptoms, even in the absence of clinically diagnosed peripheral changes. (AU)

• Processo FAPESP: 10/14804-6 - Imagem de SPECT com [99mTc] ECD em pacientes com zumbido crônico após o tratamento por acupuntura
• Beneficiário: Andrea Parolin Jackowski
• Modalidade de apoio: Auxílio à Pesquisa - Regular