FTO Genotype, Vitamin D Status, and Weight Gain During Childhood

Autor(es)

Lourenco, Barbara H. ^[1] ; Qi, Lu ^[2] ; Willett, Walter C. ^[2] ; Cardoso, Marly A. ^[3] ; Team, ACTION Study

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Publ Hlth Nutr Program, Sao Paulo - Brazil

^[2] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 - USA

^[3] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Diabetes; v. 63, n. 2, p. 808-814, FEB 2014.
• Citações Web of Science: 18

Resumo

Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these effects were modified by vitamin D status, an important nutritional factor related to adiposity. At baseline, 1,088 children aged <10 years had complete genotypic and anthropometric data; 796 were followed up over a median 4.6 years. Baseline vitamin D insufficiency was defined as <75 nmol/L. We observed a 0.07 kg/m(2)/year increase in BMI and a 0.03 Z/year increase in BMI-for-age Z score per rs9939609 risk allele over follow-up (P = 0.01). Vitamin D status significantly modified FTO effects (P for interaction = 0.02). The rs9939609 risk allele was associated with a 0.05 Z/year increase in BMI-for-age Z score among vitamin D-insufficient children (P = 0.003), while no significant genetic effects were observed among vitamin D-sufficient children. Our data suggest that FTO rs9939609 affects child weight gain, and genotype effects are more pronounced among children with insufficient vitamin D levels. (AU)

• Processo FAPESP: 08/57796-3 - Crescimento infantil e composição corporal na idade escolar: estudo prospectivo de base populacional em Acrelândia, Estado do Acre, Amazônia Ocidental Brasileira
• Beneficiário: Bárbara Hatzlhoffer Lourenço
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 07/53042-1 - Saude e nutricao de criancas pre-escolares da amazonia ocidental brasileira: um estudo de coorte.
• Beneficiário: Marly Augusto Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular