The variant of CD11b, rs1143679 within ITGAM, is associated with systemic lupus erythematosus and clinical manifestations in Brazilian patients

Autor(es)

Toller-Kawahisa, Juliana Escher ^[1] ; Costa Vigato-Ferreira, Isabel Cristina ^[2] ; Tres Pancoto, Joao Alexandre ^[3] ; Mendes-Junior, Celso Teixeira ^[4] ; Martinez, Edson Zangiacomi ^[5] ; Palomino, Gustavo Martelli ^[6] ; Louzada-Junior, Paulo ^[6] ; Donadi, Eduardo Antonio ^[6] ; Cavalcanti Del Lama, Jose Eduardo ^[2] ; Marzocchi-Machado, Cleni Mara ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14049 Ribeirao Preto, SP - Brazil

^[3] Univ Fed Espirito Santo, Sao Mateus, ES - Brazil

^[4] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Social Med, BR-14049 Ribeirao Preto, SP - Brazil

^[6] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HUMAN IMMUNOLOGY; v. 75, n. 2, p. 119-123, FEB 2014.
• Citações Web of Science: 9

Resumo

Background/aims: Immune responses mediated by complement receptors (CR) are impaired in patients with systemic lupus erythematosus (SLE). Regarding CR3 (CD11b/CD18), the CD11b subunit is encoded by the ITGAM gene and a single nucleotide polymorphism (G230A; rs1143679) in ITGAM changes an arginine to a histidine at position 77 (R77H). We assessed whether the variant R77H, rs1143679 within ITGAM, is associated with the risk to developing SLE and the clinical manifestations of Brazilian SLE patients. Methods: The rs1143679 was genotyped by SSP-PCR in 157 patients with SLE and 147 healthy individuals. Clinical and laboratorial manifestations were obtained from the official medical records according the criteria of the American College of Rheumatology. Results: The 77H variant was associated with susceptibility to SLE (OR = 1.8); the frequencies of the minor allele A were 0.25 (SLE) and 0.15 (healthy) (p < 0.01). In addition, the minor allele A was associated with lupus nephritis (p = 0.02) and antiphospholipid antibodies (p = 0.04). Conclusion: These results showed that the rs1143679 variant is also associated with the risk to SLE in our population and with the risk to specific clinical manifestations, as nephritis and presence of antiphospholipid antibodies. These results may have implications for discussing the association of this polymorphism with the IC deposition in SLE. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 09/12649-6 - Associação dos polimorfismos dos FcgamaR e do CR3 com as infecções bacterianas no lúpus eritematoso sistêmico: determinação das combinações dos genótipos e sua influência no burst oxidativo dos neutrófilos
• Beneficiário: Juliana Escher Toller
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 09/14732-8 - Associação dos polimorfismos dos FcgamaR e do CR3 com as infecções bacterianas no lúpus eritematoso sistêmico: determinação das combinações dos genótipos e sua influência nas funções mediadas por neutrófilos
• Beneficiário: Cleni Mara Marzocchi Machado
• Modalidade de apoio: Auxílio à Pesquisa - Regular