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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Phase quantification of antihypertensive drugs - Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide - by the Rietveld method

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Autor(es):
do Carmo, Weberton Reis [1] ; Ferreira, Fabio Furlan [2] ; Diniz, Renata [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Fed Juiz de Fora, Dept Quim ICE, BR-36036330 Juiz De Fora, MG - Brazil
[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Journal of Pharmaceutical and Biomedical Analysis; v. 88, p. 152-156, JAN 25 2014.
Citações Web of Science: 0
Resumo

The identification and quantification of crystalline phases of antihypertensive drugs - Losartan potassium (LOS-K), Hydrochlorothiazide (HCTZ) and Chlorthalidone (CTD) were carried out by means of X-ray powder diffraction data and the Rietveld method. Quantitative phase analyses of Losartan potassium/Chlorthalidone (LOS-K/CTD) and Losartan potassium/Hydrochlorothiazide (LOS-K/HCTZ) combinations were also evaluated. The results indicated that for diuretics (HCTZ and CTD) only one crystalline phase was found in samples, and for LOS-K the crystal structure showed similarity between the Bragg peaks to the phase described as monoclinic and space group P2(1)/c. After one year storage, the orthorhombic one was also observed in this sample. (C) 2013 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 08/10537-3 - Estudo de polimorfos de fármacos cristalinos através da difração de raios X por policristais e do método de Rietveld
Beneficiário:Fabio Furlan Ferreira
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores