Phase quantification of antihypertensive drugs - Chlorthalidone, Hydrochlorothiazide, Losartan and combinations, Losartan/Chlorthalidone and Losartan/Hydrochlorothiazide - by the Rietveld method

Author(s)

do Carmo, Weberton Reis ^[1] ; Ferreira, Fabio Furlan ^[2] ; Diniz, Renata ^[1]

Affiliation

^[1] Univ Fed Juiz de Fora, Dept Quim ICE, BR-36036330 Juiz De Fora, MG - Brazil

^[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Sao Paulo - Brazil

• Document type: Journal article
• Source: Journal of Pharmaceutical and Biomedical Analysis; v. 88, p. 152-156, JAN 25 2014.
• Web of Science Citations: 0

Abstract

The identification and quantification of crystalline phases of antihypertensive drugs - Losartan potassium (LOS-K), Hydrochlorothiazide (HCTZ) and Chlorthalidone (CTD) were carried out by means of X-ray powder diffraction data and the Rietveld method. Quantitative phase analyses of Losartan potassium/Chlorthalidone (LOS-K/CTD) and Losartan potassium/Hydrochlorothiazide (LOS-K/HCTZ) combinations were also evaluated. The results indicated that for diuretics (HCTZ and CTD) only one crystalline phase was found in samples, and for LOS-K the crystal structure showed similarity between the Bragg peaks to the phase described as monoclinic and space group P2(1)/c. After one year storage, the orthorhombic one was also observed in this sample. (C) 2013 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 08/10537-3 - Study of crystalline pharmaceuticals polymorphs by X-ray powder diffraction and the Rietveld method
• Grantee: Fabio Furlan Ferreira
• Support Opportunities: Research Grants - Young Investigators Grants