Complex networks: the key to systems biology

Autor(es)

Luciano da F. Costa ^[1] ; Francisco A. Rodrigues ^[1] ; Alexandre S. Cristino ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Fis, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 31, n. 3, p. 591-601, 2008-00-00.

Resumo

Though introduced recently, complex networks research has grown steadily because of its potential to represent, characterize and model a wide range of intricate natural systems and phenomena. Because of the intrinsic complexity and systemic organization of life, complex networks provide a specially promising framework for systems biology investigation. The current article is an up-to-date review of the major developments related to the application of complex networks in biology, with special attention focused on the more recent literature. The main concepts and models of complex networks are presented and illustrated in an accessible fashion. Three main types of networks are covered: transcriptional regulatory networks, protein-protein interaction networks and metabolic networks. The key role of complex networks for systems biology is extensively illustrated by several of the papers reviewed. (AU)

• Processo FAPESP: 05/00587-5 - Modelagem por redes (grafos) e técnicas de reconhecimento de padrões: estrutura, dinâmica e aplicações
• Beneficiário: Roberto Marcondes Cesar Junior
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/50633-9 - Redes complexas: uma abordagem por mineracao de dados.
• Beneficiário: Francisco Aparecido Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 06/61232-2 - Redes complexas aplicadas à genética e à biologia do desenvolvimento
• Beneficiário: Alexandre dos Santos Cristino
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado