Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Complex networks: the key to systems biology

Full text
Author(s):
Luciano da F. Costa [1] ; Francisco A. Rodrigues [1] ; Alexandre S. Cristino [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Fis, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: GENETICS AND MOLECULAR BIOLOGY; v. 31, n. 3, p. 591-601, 2008-00-00.
Abstract

Though introduced recently, complex networks research has grown steadily because of its potential to represent, characterize and model a wide range of intricate natural systems and phenomena. Because of the intrinsic complexity and systemic organization of life, complex networks provide a specially promising framework for systems biology investigation. The current article is an up-to-date review of the major developments related to the application of complex networks in biology, with special attention focused on the more recent literature. The main concepts and models of complex networks are presented and illustrated in an accessible fashion. Three main types of networks are covered: transcriptional regulatory networks, protein-protein interaction networks and metabolic networks. The key role of complex networks for systems biology is extensively illustrated by several of the papers reviewed. (AU)

FAPESP's process: 05/00587-5 - Mesh (graph) modeling and techniques of pattern recognition: structure, dynamics and applications
Grantee:Roberto Marcondes Cesar Junior
Support Opportunities: Research Projects - Thematic Grants