| Texto completo | |
| Autor(es): |
Trinconi, Cristiana T.
[1]
;
Reimao, Juliana Q.
[1]
;
Yokoyama-Yasunaka, Jenicer K. U.
[1]
;
Miguel, Danilo C.
[1]
;
Uliana, Silvia R. B.
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508 Sao Paulo - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Antimicrobial Agents and Chemotherapy; v. 58, n. 5, p. 2608-2613, MAY 2014. |
| Citações Web of Science: | 24 |
| Resumo | |
Leishmaniasis chemotherapy remains very challenging. The high cost of active drugs, along with the severity of their side effects and the increasing failure rate of the current therapeutic schemes, calls for the discovery of new active drugs and schemes of treatment. The use of combination therapy has gained much attention in recent years as a possible strategy for overcoming the various shortcomings in the present arsenal. We recently described the effectiveness of tamoxifen in murine models of leishmaniasis, and here, we investigated the interactions between tamoxifen and amphotericin B, one of the most potent drugs used in leishmaniasis treatment. The in vitro interactions were indifferent for the association of tamoxifen and amphotericin B. The association was also assayed in vivo in Leishmania amazonensis-infected BALB/c mice and was found to yield at least additive effects at low doses of both drugs. (AU) | |
| Processo FAPESP: | 11/20484-7 - Tamoxifeno no tratamento de leishmaniose: avaliação de eficácia em esquemas de combinação de drogas e estudo do mecanismo de ação |
| Beneficiário: | Silvia Reni Bortolin Uliana |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/18858-6 - Tamoxifeno como droga anti-leishmania: atividade em esquemas terapêuticos combinados e estudo do mecanismo de ação |
| Beneficiário: | Cristiana de Melo Trinconi Tronco |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |