| Texto completo | |
| Autor(es): Mostrar menos - |
Lopes, Stefanie C. P.
[1, 2]
;
Albrecht, Letusa
[2]
;
Carvalho, Bruna O.
[2]
;
Siqueira, Andre M.
[1, 3]
;
Thomson-Luque, Richard
[1, 4]
;
Nogueira, Paulo A.
[5]
;
Fernandez-Becerra, Carmen
[4]
;
del Portillo, Hernando A.
[6, 4]
;
Russell, Bruce M.
[7, 8]
;
Renia, Laurent
[7]
;
Lacerda, Marcus V. G.
[1, 3]
;
Costa, Fabio T. M.
[2]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas - Brazil
[2] Univ Estadual Campinas, Dept Genet Evolucao & Bioagentes, Inst Biol, Campinas, SP - Brazil
[3] Univ Estado Amazonas, Manaus, Amazonas - Brazil
[4] CRESIB, Barcelona Ctr Int Hlth Res, Barcelona - Spain
[5] Fiocruz MS, Inst Leonidas & Maria Deane, Manaus, Amazonas - Brazil
[6] ICREA, Barcelona - Spain
[7] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore - Singapore
[8] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol, Singapore 117595 - Singapore
Número total de Afiliações: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Infectious Diseases; v. 209, n. 9, p. 1403-1407, MAY 1 2014. |
| Citações Web of Science: | 25 |
| Resumo | |
There is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration. (AU) | |
| Processo FAPESP: | 12/16525-2 - Plasmodium vivax: patogênese e infectividade |
| Beneficiário: | Fabio Trindade Maranhão Costa |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |