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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Paucity of Plasmodium vivax Mature Schizonts in Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential

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Author(s):
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Lopes, Stefanie C. P. [1, 2] ; Albrecht, Letusa [2] ; Carvalho, Bruna O. [2] ; Siqueira, Andre M. [1, 3] ; Thomson-Luque, Richard [1, 4] ; Nogueira, Paulo A. [5] ; Fernandez-Becerra, Carmen [4] ; del Portillo, Hernando A. [6, 4] ; Russell, Bruce M. [7, 8] ; Renia, Laurent [7] ; Lacerda, Marcus V. G. [1, 3] ; Costa, Fabio T. M. [2]
Total Authors: 12
Affiliation:
[1] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas - Brazil
[2] Univ Estadual Campinas, Dept Genet Evolucao & Bioagentes, Inst Biol, Campinas, SP - Brazil
[3] Univ Estado Amazonas, Manaus, Amazonas - Brazil
[4] CRESIB, Barcelona Ctr Int Hlth Res, Barcelona - Spain
[5] Fiocruz MS, Inst Leonidas & Maria Deane, Manaus, Amazonas - Brazil
[6] ICREA, Barcelona - Spain
[7] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore - Singapore
[8] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol, Singapore 117595 - Singapore
Total Affiliations: 8
Document type: Journal article
Source: Journal of Infectious Diseases; v. 209, n. 9, p. 1403-1407, MAY 1 2014.
Web of Science Citations: 25
Abstract

There is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration. (AU)

FAPESP's process: 12/16525-2 - Plasmodium vivax: pathogenesis and infectivity
Grantee:Fabio Trindade Maranhão Costa
Support Opportunities: Research Projects - Thematic Grants