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Analyses of the immunopathological and molecular mechanisms involved in cytoadherence of Plasmodium vivax

Grant number: 13/20509-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2014
Effective date (End): March 03, 2019
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Fabio Trindade Maranhão Costa
Grantee:Catarina Baeta da Luz Bourgard
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:12/16525-2 - Plasmodium vivax: pathogenesis and infectivity, AP.TEM
Associated scholarship(s):18/00613-6 - Plasmodium vivax: whole transcriptome shotgun sequencing data analysis, BE.EP.DR   16/11764-0 - Plasmodium vivax: whole transcriptome shotgun sequencing data analysis, BE.EP.DR

Abstract

Plasmodium vivax is responsible for more than 80 million cases per year worldwide, with strong social impact outside Africa, mainly in Asia and the Americas. Brazil accounts for 50-60% of all cases of malaria reported in the Americas, in which 85% of infections are caused by P. vivax, wherein are restricted almost exclusively to the Amazon region (99.8%). It was recently found that P. vivax infection could also progress to severe disease, pathologically similar to P. falciparum cases. These observations challenge the pre-established view that P. vivax parasite is a "benign". Indeed, we have shown that P. vivax-infected erythrocytes (Pv-iE) collected from infected patients are able to adhere to the placenta and to lung and brain endothelia. Also, we have recently observed a low frequency in peripheral circulating P. vivax schizonts harvested from infected patients and a high adhesive capacity of these forms; therefore indicating that these stage-forms could be sequestered into deep microvasculature. However, studies on P. vivax biology, by means of functional assays, remain constrained to endemic hospitals due to the inability of cultivating this parasite in vitro and during long periods. In this sense and in collaboration with the Foundation for Tropical Medicine, Heitor Vieira Dourado (FMT-HVD, Manaus-AM), we intend to elucidate the immunopathological and molecular mechanisms involved in P. vivax cytoadherence to endothelial cells, (i) by means of identification of novel endothelial receptors and parasite ligands involved in this process, and (ii) assessing the role of plasma mediators that may be involved in Pv-iE adhesion via endothelial modulation.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALBRECHT, LETUSA; LOPES, STEFANIE C. P.; IUNG ENEMBRECK DA SILVA, ANA BEATRIZ; BARBOSA, VANESSA; ALMEIDA, RODRIGO P.; SIQUEIRA, ANDRE M.; LEITE, JULIANA ALMEIDA; BITTENCOURT, NAJARA C.; DOS SANTOS, HELLEN GEREMIAS; BOURGARD, CATARINA; et al. Rosettes integrity protects Plasmodium vivax of being phagocytized. SCIENTIFIC REPORTS, v. 10, n. 1, . (13/20509-5, 12/16525-2, 13/25807-4, 17/18611-7)
BOURGARD, CATARINA; ALBRECHT, LETUSA; KAYANO, ANA C. A. V.; SUNNERHAGEN, PER; COSTA, FABIO T. M.. Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 8, . (12/16525-2, 13/20509-5)
BITTENCOURT, NAJARA C.; LEITE, JULIANA A.; SILVA, ANA BEATRIZ I. E.; PIMENTA, TAMIRYS S.; SILVA-FILHO, JOAO LUIZ; CASSIANO, GUSTAVO C.; LOPES, STEFANIE C. P.; DOS-SANTOS, JOAO C. K.; BOURGARD, CATARINA; NAKAYA, HELDER I.; et al. Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2). Malaria Journal, v. 17, . (13/20509-5, 15/02808-0, 15/20774-6, 12/16525-2, 13/25807-4, 16/12855-9)
BOURGARD, CATARINA; LOPES, STEFANIE C. P.; LACERDA, MARCUS V. G.; ALBRECHT, LETUSA; COSTA, FABIO T. M.. A suitable RNA preparation methodology for whole transcriptome shotgun sequencing harvested from Plasmodium vivax-infected patients. SCIENTIFIC REPORTS, v. 11, n. 1, . (12/16525-2, 13/20509-5, 17/18611-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BOURGARD, Catarina Baeta da Luz. Análises dos mecanismos imunopatológicos e moleculares envolvidos no processo de citoaderência de Plasmodium vivax. 2019. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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