Intracranial teratoma in children: The role of chromosome 21 trisomy

Autor(es)

Ferraz, Sabrine Teixeira ^[1] ; Valera, Elvis Terci ^[1] ; Brassesco, Maria Sol ^[2] ; de Oliveira, Ricardo Santos ^[3] ; dos Santos, Antonio Carlos ^[4] ; Saggioro, Fabiano Pinto ^[5] ; Neder, Luciano ^[5] ; Scrideli, Carlos Alberto ^[1] ; Tone, Luiz Gonzaga ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Philosophy Sci & Letters, Dept Pediat, Div Pediat Oncol, BR-14049 Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Sch Philosophy Sci & Letters, Dept Biol, BR-14049 Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Univ Hosp Ribeirao Preto Med Sch, Dept Surg & Anat, Div Pediat Neurosurg, BR-14049 Ribeirao Preto - Brazil

^[4] Univ Sao Paulo, Univ Hosp Ribeirao Preto Med Sch, Div Radiol, BR-14049 Ribeirao Preto - Brazil

^[5] Univ Sao Paulo, Univ Hosp Ribeirao Preto Med Sch, Dept Pathol, BR-14049 Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEUROPATHOLOGY; v. 34, n. 2, p. 197-200, APR 2014.
• Citações Web of Science: 2

Resumo

Teratomas are very rare intracranial tumors and cytogenetic information on this group remains rare. We report a case of a mature teratoma with abnormal +21 trisomy in tumor karyotype ocurring in a non-Down syndrome (DS) infant. Additionally, the evidence for the contribution of chromosome 21 trisomy in this neoplasia are briefly reviewed. The 6-month-old male baby presented with a posterior fossa tumor. Histological evaluation of tumor specimen showed a mature teratoma composed of fully differentiated ectodermal, mesodermal and endodermal components. Although somatic karyotyping of the index case was normal, composite tumor karyotype depicted 47, XY, +21{[}6]/46,XY{[}6]. Besides previous reports of children with DS and intracranial teratomas, this is the first report to describe the occurrence of an isolated chromosome 21 trisomy within the tumor of a non-DS child. The participation of chromosome 21 in this rare pediatric tumor, either somatic or restricted to tumor specimen, may deserve special interest and further investigation. (AU)

• Processo FAPESP: 10/15717-0 - Análise de aberrações cromossômicas em neoplasias da Infância através de citogenética convencional e Hibridização in situ fluorescente (FISH)
• Beneficiário: Elvis Terci Valera
• Modalidade de apoio: Auxílio à Pesquisa - Regular