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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intracranial teratoma in children: The role of chromosome 21 trisomy

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Author(s):
Ferraz, Sabrine Teixeira [1] ; Valera, Elvis Terci [1] ; Brassesco, Maria Sol [2] ; de Oliveira, Ricardo Santos [3] ; dos Santos, Antonio Carlos [4] ; Saggioro, Fabiano Pinto [5] ; Neder, Luciano [5] ; Scrideli, Carlos Alberto [1] ; Tone, Luiz Gonzaga [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Sch Philosophy Sci & Letters, Dept Pediat, Div Pediat Oncol, BR-14049 Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Sch Philosophy Sci & Letters, Dept Biol, BR-14049 Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Univ Hosp Ribeirao Preto Med Sch, Dept Surg & Anat, Div Pediat Neurosurg, BR-14049 Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Univ Hosp Ribeirao Preto Med Sch, Div Radiol, BR-14049 Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Univ Hosp Ribeirao Preto Med Sch, Dept Pathol, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 5
Document type: Journal article
Source: NEUROPATHOLOGY; v. 34, n. 2, p. 197-200, APR 2014.
Web of Science Citations: 2
Abstract

Teratomas are very rare intracranial tumors and cytogenetic information on this group remains rare. We report a case of a mature teratoma with abnormal +21 trisomy in tumor karyotype ocurring in a non-Down syndrome (DS) infant. Additionally, the evidence for the contribution of chromosome 21 trisomy in this neoplasia are briefly reviewed. The 6-month-old male baby presented with a posterior fossa tumor. Histological evaluation of tumor specimen showed a mature teratoma composed of fully differentiated ectodermal, mesodermal and endodermal components. Although somatic karyotyping of the index case was normal, composite tumor karyotype depicted 47, XY, +21{[}6]/46,XY{[}6]. Besides previous reports of children with DS and intracranial teratomas, this is the first report to describe the occurrence of an isolated chromosome 21 trisomy within the tumor of a non-DS child. The participation of chromosome 21 in this rare pediatric tumor, either somatic or restricted to tumor specimen, may deserve special interest and further investigation. (AU)

FAPESP's process: 10/15717-0 - Analysis of chromosomal aberrations in childhood cancer through conventional and molecular cytogenetics
Grantee:Elvis Terci Valera
Support Opportunities: Regular Research Grants