Passiflora edulis peel intake and ulcerative colitis: Approaches for prevention and treatment

Autor(es):Mostrar menos -

Cazarin, Cinthia B. B. ^[1] ; da Silva, Juliana K. ^[1] ; Colomeu, Talita C. ^[2] ; Batista, Angela G. ^[1] ; Vilella, Conceicao A. ^[2] ; Ferreira, Anderson L. ^[3] ; Bogusz Junior, Stanislau ^[4] ; Fukuda, Karina ^[4] ; Augusto, Fabio ^[4] ; de Meirelles, Luciana R. ^[5] ; Zollner, Ricardo de L. ^[2] ; Marostica Junior, Mario R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, BR-13083862 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, BR-13083887 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Dept Struct & Funct Biol, BR-13083862 Campinas, SP - Brazil

^[4] Univ Estadual Campinas, Inst Chem, Inst Nacl Ciencia & Tecnol Bioanalit INCTBio, BR-13083970 Campinas, SP - Brazil

^[5] Univ Estadual Campinas, Dept Pathol, Fac Med Sci, BR-13083887 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Experimental Biology and Medicine; v. 239, n. 5, p. 542-551, MAY 2014.
• Citações Web of Science: 15

Resumo

Inflammatory bowel disease is a chronic relapsing disease that affects millions of people worldwide; its pathogenesis is influenced by genetic, environmental, microbiological, and immunological factors. The aim of this study was to evaluate the effects of short- and long-term Passiflora edulis peel intake on the antioxidant status, microbiota, and short-chain fatty acids formation in rats with 2,4,6-trinitrobenzenesulphonic acid-induced colitis using two ``in vivo{''} experiments: chronic (prevention) and acute (treatment). The colitis damage score was determined using macroscopic and microscopic analyses. In addition, the antioxidant activity in serum and other tissues (liver and colon) was evaluated. Bifidobacteria, lactobacilli, aerobic bacteria and enterobacteria, and the amount of short-chain fatty acids (acetic, butyric, and propionic acids) in cecum content were counted. Differences in the colon damage scores were observed; P. edulis peel intake improved serum antioxidant status. In the treatment protocol, decreased colon lipid peroxidation, a decreased number of aerobic bacteria and enterobacteria, and an improvement in acetic and butyric acid levels in the feces were observed. An improvement in the bifidobacteria and lactobacilli was observed in the prevention protocol. These results suggested that P. edulis peel can modulate microbiota and could be used as source of fiber and polyphenols in the prevention of oxidative stress through the improvement of serum and tissue antioxidant status. (AU)

• Processo FAPESP: 10/16752-3 - Avaliação do consumo da casca de Passiflora edulis e seu impacto na inflamação intestinal de ratos com colite ulcerativa.
• Beneficiário: Cinthia Baú Betim Cazarin
• Modalidade de apoio: Bolsas no Brasil - Doutorado