Is there any relationship between gene expression of tumor antigens and CD4(+) T cells in multiple myeloma?

Autor(es)

Braga, Walter M. T. ; da Silva, Bruna R. ^[1] ; Alves, Veruska L. F. ^[1] ; Bortoluzo, Adriana B. ^[2] ; Atanackovic, Djordje ^[3] ; Colleoni, Gisele W. B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Disciplina Hematol & Hemoterapia, Dept Oncol Clin & Expt, Sao Paulo - Brazil

^[2] Insper Inst Educ & Res, Sao Paulo - Brazil

^[3] Univ Med Ctr Hamburg Eppendorf, Hamburg - Germany

• Tipo de documento: Artigo Científico
• Fonte: Immunotherapy; v. 6, n. 5, p. 569-575, MAY 2014.
• Citações Web of Science: 1

Resumo

Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells. Materials \& methods: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4(+) T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4(+) T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM. (AU)

• Processo FAPESP: 10/17668-6 - Identificação de marcadores tumorais e possíveis alvos terapêuticos em doenças linfoproliferativas de células B
• Beneficiário: Gisele Wally Braga Colleoni
• Modalidade de apoio: Auxílio à Pesquisa - Temático