| Full text | |
| Author(s): |
Braga, Walter M. T.
;
da Silva, Bruna R.
[1]
;
Alves, Veruska L. F.
[1]
;
Bortoluzo, Adriana B.
[2]
;
Atanackovic, Djordje
[3]
;
Colleoni, Gisele W. B.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Sao Paulo, Disciplina Hematol & Hemoterapia, Dept Oncol Clin & Expt, Sao Paulo - Brazil
[2] Insper Inst Educ & Res, Sao Paulo - Brazil
[3] Univ Med Ctr Hamburg Eppendorf, Hamburg - Germany
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Immunotherapy; v. 6, n. 5, p. 569-575, MAY 2014. |
| Web of Science Citations: | 1 |
| Abstract | |
Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells. Materials \& methods: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4(+) T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4(+) T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM. (AU) | |
| FAPESP's process: | 10/17668-6 - Identification of biomarkers and possible therapeutical targets in B-cell lymphoproliferative disorders |
| Grantee: | Gisele Wally Braga Colleoni |
| Support Opportunities: | Research Projects - Thematic Grants |