Atherogenic lipid profile of Brazilian near-term newborns

Autor(es)

I.M.C.G. Pardo ^[1] ; B. Geloneze ^[2] ; M.A. Tambascia ^[3] ; A.A. Barros-Filho ^[4]

Afiliação do(s) autor(es)

^[1] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Pediatria

^[2] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Endocrinologia e Metabolismo - Brasil

^[3] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Endocrinologia e Metabolismo - Brasil

^[4] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Pediatria

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 38, n. 5, p. 755-760, 2005-05-00.

Resumo

Cardiovascular disease is the primary cause of death in Brazil. Recent studies have shown that low birth weight and preterm birth are linked to a higher prevalence of cardiovascular disease. The aim of the present study was to compare the levels of lipids and apolipoproteins and atherogenic indexes between term and near-term newborn infants. A sample of umbilical cord blood was obtained from 135 newborns (66 males) divided into two groups: 25 near-term neonates (35-36.6 weeks of gestational age) and 110 term neonates (37-42 weeks of gestational age). The total cholesterol concentrations were higher in the near-term neonates than in the term group (94.04 ± 8.02 vs 70.42 ± 1.63 mg/dl, P < 0.01), due to an increase in the LDL-cholesterol fraction in the near-term group (57.76 ± 6.39 vs 34.38 ± 1.29 mg/dl, P < 0.001). The atherogenic indexes (total cholesterol/HDL-cholesterol, LDL-cholesterol/HDL-cholesterol and apolipoprotein B/apolipoprotein A-I) were higher in the near-term group (P < 0.001, P < 0.001, and P < 0.05, respectively). The gestational age of the newborns was inversely correlated with total cholesterol and LDL-cholesterol, and also with the total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol indexes. These findings demonstrate that the lipid profile is worse in the group of near-term neonates compared with the term group. Future studies are needed to determine if this atherogenic profile in near-term neonates can affect body metabolism, increasing the risk for cardiovascular diseases in adult life. (AU)

• Processo FAPESP: 01/04402-9 - Ha relacao entre leptina do sangue do coracao umbilical e crescimento fetal?
• Beneficiário: Antonio de Azevedo Barros Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular