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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Atherogenic lipid profile of Brazilian near-term newborns

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Author(s):
I.M.C.G. Pardo [1] ; B. Geloneze [2] ; M.A. Tambascia [3] ; A.A. Barros-Filho [4]
Total Authors: 4
Affiliation:
[1] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Pediatria
[2] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Endocrinologia e Metabolismo - Brasil
[3] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Endocrinologia e Metabolismo - Brasil
[4] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Pediatria
Total Affiliations: 4
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 38, n. 5, p. 755-760, 2005-05-00.
Abstract

Cardiovascular disease is the primary cause of death in Brazil. Recent studies have shown that low birth weight and preterm birth are linked to a higher prevalence of cardiovascular disease. The aim of the present study was to compare the levels of lipids and apolipoproteins and atherogenic indexes between term and near-term newborn infants. A sample of umbilical cord blood was obtained from 135 newborns (66 males) divided into two groups: 25 near-term neonates (35-36.6 weeks of gestational age) and 110 term neonates (37-42 weeks of gestational age). The total cholesterol concentrations were higher in the near-term neonates than in the term group (94.04 ± 8.02 vs 70.42 ± 1.63 mg/dl, P < 0.01), due to an increase in the LDL-cholesterol fraction in the near-term group (57.76 ± 6.39 vs 34.38 ± 1.29 mg/dl, P < 0.001). The atherogenic indexes (total cholesterol/HDL-cholesterol, LDL-cholesterol/HDL-cholesterol and apolipoprotein B/apolipoprotein A-I) were higher in the near-term group (P < 0.001, P < 0.001, and P < 0.05, respectively). The gestational age of the newborns was inversely correlated with total cholesterol and LDL-cholesterol, and also with the total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol indexes. These findings demonstrate that the lipid profile is worse in the group of near-term neonates compared with the term group. Future studies are needed to determine if this atherogenic profile in near-term neonates can affect body metabolism, increasing the risk for cardiovascular diseases in adult life. (AU)