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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Changes in prolactin secretion in the short- and long-term after adrenalectomy

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Autor(es):
Laguna-Abreu, Maria Thereza C. [1] ; Germano, Carla [2] ; Moreira, Ayrton C. [2] ; Antunes-Rodrigues, Jose [3] ; Elias, Lucila [3] ; Castro, Margaret [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Uberaba Uniube, Lab Mol Biol & Biopathol, Uberaba, MG - Brazil
[2] Univ Sao Paulo FMRP USP, Dept Internal Med, Div Endocrinol, Sch Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] FMRP USP, Dept Physiol, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 56, n. 4, p. 244-249, JUN 2012.
Citações Web of Science: 1
Resumo

Objective: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). Materials and methods: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). Results: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. Conclusion: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX. Arq Bras Endocrinol Metab. 2012;56(4):244-9 (AU)

Processo FAPESP: 02/06001-4 - Regulação da expressão dos receptores do hormônio liberador da corticotrofina ( CRH-R1, CRH-R2a e CRH-R2b) e da vasopressina (V1b) após diferentes períodos de adrenalectomia (ADX): efeitos do estresse
Beneficiário:Maria Theresa Cerávolo Laguna
Modalidade de apoio: Bolsas no Brasil - Doutorado