Changes in prolactin secretion in the short- and long-term after adrenalectomy

Autor(es)

Laguna-Abreu, Maria Thereza C. ^[1] ; Germano, Carla ^[2] ; Moreira, Ayrton C. ^[2] ; Antunes-Rodrigues, Jose ^[3] ; Elias, Lucila ^[3] ; Castro, Margaret ^[2]

Afiliação do(s) autor(es)

^[1] Univ Uberaba Uniube, Lab Mol Biol & Biopathol, Uberaba, MG - Brazil

^[2] Univ Sao Paulo FMRP USP, Dept Internal Med, Div Endocrinol, Sch Med Ribeirao Preto, Ribeirao Preto, SP - Brazil

^[3] FMRP USP, Dept Physiol, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 56, n. 4, p. 244-249, JUN 2012.
• Citações Web of Science: 1

Resumo

Objective: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). Materials and methods: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). Results: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. Conclusion: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX. Arq Bras Endocrinol Metab. 2012;56(4):244-9 (AU)

• Processo FAPESP: 02/06001-4 - Regulação da expressão dos receptores do hormônio liberador da corticotrofina ( CRH-R1, CRH-R2a e CRH-R2b) e da vasopressina (V1b) após diferentes períodos de adrenalectomia (ADX): efeitos do estresse
• Beneficiário: Maria Theresa Cerávolo Laguna
• Modalidade de apoio: Bolsas no Brasil - Doutorado