| Full text | |
| Author(s): |
Laguna-Abreu, Maria Thereza C.
[1]
;
Germano, Carla
[2]
;
Moreira, Ayrton C.
[2]
;
Antunes-Rodrigues, Jose
[3]
;
Elias, Lucila
[3]
;
Castro, Margaret
[2]
Total Authors: 6
|
| Affiliation: | [1] Univ Uberaba Uniube, Lab Mol Biol & Biopathol, Uberaba, MG - Brazil
[2] Univ Sao Paulo FMRP USP, Dept Internal Med, Div Endocrinol, Sch Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] FMRP USP, Dept Physiol, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Endocrinologia e Metabologia; v. 56, n. 4, p. 244-249, JUN 2012. |
| Web of Science Citations: | 1 |
| Abstract | |
Objective: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). Materials and methods: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). Results: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. Conclusion: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX. Arq Bras Endocrinol Metab. 2012;56(4):244-9 (AU) | |