Dietary glycemic load, glycemic index, and refined grains intake are associated with reduced beta-cell function in prediabetic Japanese migrants

Autor(es)

Sartorelli, Daniela Saes ^[1] ; Franco, Laercio Joel ^[1] ; Damiao, Renata ^[2] ; Gimeno, Suely ^[3] ; Cardoso, Marly Augusto ^[4] ; Gouvea Ferreira, Sandra Roberta ^{[3, 4]} ; Gr, Japanese-Brazilian Diabet Study

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Social Med, Ribeirao Preto, SP - Brazil

^[2] Univ Fed Triangulo Mineiro, Dept Nutr, Uberaba, MG - Brazil

^[3] Univ Fed Sao Paulo, Dept Prevent Med, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Nutr, Fac Saude Publ, BR-09500900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 53, n. 4, p. 429-434, JUN 2009.
• Citações Web of Science: 4

Resumo

Objective: To investigate the association between carbohydrate intakes and beta-cell function (HOMA-beta) in Japanese-Brazilians with impaired glucose tolerance (IGT). Methods: Dietary intakes were assessed by a validated food frequency questionnaire in a cross-sectional survey carried out in 2000. The associations between diet and HOMA-beta were verified in 270 newly diagnosed IGT in multiple linear regression models. Results: The mean (SD) age was 58 (11) years and the mean HOMA-beta was 65 (47). The glycemic load was inversely associated with HOMA-beta, beta 1 -0.140 (95% CI = -1.044; - 0.078), p = 0.023. The inverse association was also observed for refined grains intakes: -0.186 (95% CI = - 0.4862; -0.058), p = 0.012. After adjustments for body mass index, the glycemic index was inversely associated with HOMA-beta: -0.1246 (95% CI = -2.2482, -0.0257), p < 0.001. Conclusions: These data suggested that dietary glycemic load, glycemic index, and refined grains intakes are associated with reduced beta-cell function, and the quality of dietary carbohydrates may be relevant for maintaining beta-cell function among individuals with IGT. Arq Bras Endocrinol Metab. 2009; 53(4): 429-34. (AU)

• Processo FAPESP: 98/04178-7 - Diabetes mellitus e doenças associadas na comunidade nipo-brasileira de Bauru: segunda fase
• Beneficiário: Sandra Roberta Gouvea Ferreira Vivolo
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 02/13450-0 - Estudo transversal sobre padrões alimentares, índice glicêmico e alteração da homeostase glicêmica na população nipo-brasileira de Bauru, SP
• Beneficiário: Daniela Saes Sartorelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado