Interactions of polymorphisms in different clock genes associated with circadian phenotypes in humans

Autor(es)

Pedrazzoli, Mario ^[1] ; Secolin, Rodrigo ^[2] ; Bastos Esteves, Luiz Otavio ^[3] ; Pereira, Danyella Silva ^[3] ; Koike, Bruna Del Vechio ^[3] ; Louzada, Fernando Mazzili ^[4] ; Lopes-Cendes, Iscia ^[2] ; Tufik, Sergio ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, BR-03828000 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Dept Med Genet, Campinas, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil

^[4] Univ Fed Parana, Dept Fisiol, BR-80060000 Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 33, n. 4, p. 627-632, 2010.
• Citações Web of Science: 7

Resumo

Several studies have shown that mutations and polymorphisms in clock genes are associated with abnormal circadian parameters in humans and also with more subtle non-pathological phenotypes like chronotypes. However, there have been conflicting results, and none of these studies analyzed the combined effects of more than one clock gene. Up to date, association studies in humans have focused on the analysis of only one clock gene per study. Since these genes encode proteins that physically interact with each other, combinations of polymorphisms in different clock genes could have a synergistic or an inhibitory effect upon circadian phenotypes. In the present study, we analyzed the combined effects of four polymorphisms in four clock genes (Per2, Per3, Clock and Bmal1) in people with extreme diurnal preferences (morning or evening). We found that a specific combination of polymorphisms in these genes is more frequent in people who have a morning preference for activity and there is a different combination in individuals with an evening preference for activity. Taken together, these results show that it is possible to detect clock gene interactions associated with human circadian phenotypes and bring an innovative idea of building a clock gene variation map that may be applied to human circadian biology. (AU)

• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs