| Texto completo | |
| Autor(es): |
Rodrigues, Rosangela
[1]
;
Manenti, Sandra
[2]
;
Torres Romao, Pedro Roosevelt
[3]
;
de Paula Ferreira, Joao Leandro
[4]
;
Gervasio Batista, Joao Paulo
[5]
;
Almeida Carvalho Siqueira, Antonio Flavio
[6]
;
de Macedo Brigido, Luis Fernando
[7]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Inst Adolfo Lutz Registro. Retrovirus Lab
[2] Univ Extremo Catarinense. Lab Imunol & Mutagenese
[3] Univ Extremo Catarinense. Lab Imunol & Mutagenese
[4] Inst Adolfo Lutz Registro. Retrovirus Lab
[5] Inst Adolfo Lutz Registro. Retrovirus Lab
[6] Inst Adolfo Lutz Registro. Retrovirus Lab
[7] Inst Adolfo Lutz Registro. Retrovirus Lab
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | AIDS Research and Human Retroviruses; v. 26, n. 3, p. 351-357, MAR 2010. |
| Citações Web of Science: | 12 |
| Resumo | |
Southern Brazil has the highest prevalence rate of AIDS in the country and is the only region in the Americas where HIV-1 C prevails. Metropolitan areas and harbor cities have been evaluated, but limited information is available for small towns and specific populations. We studied women attending the obstetric outpatient clinic of Criciuma, State of Santa Catarina in 2007 to evaluate the molecular epidemiology of HIV-1 among pregnant women living with HIV/AIDS. Forty-two cases had partial pol gene sequenced and additional partial gag and/or env genes from nine women. HIV subtyping was evaluated by phylogenetic methods and antiretroviral (ARV) drug resistance mutations (DRMs) at the Stanford Database. DRMs to one or more ARV class was observed in 20/42, 48% of cases, with 15/41, 37% with viral load <500 copies/ml. Subtype C at pol was identified in 33/42, 78.6% (95% CI: 64-89%), C mosaics (CB, CF) in 2, 4.8% (95% CI: 0.8-19%), F in 4, 9.5% (95% CI: 3-21%), and B in 3, 7.1% (95% CI: 1.8-18%). Discordance in concatenated gag/pol/env or intraregion mosaic was observed in 1/9, 11% of HIV-1 C genomes. The proportion of HIV-1 C in this study is the highest rate described in the Americas. Molecular surveillance in specific populations is instrumental for a better understanding of the Brazilian HIV epidemic. (AU) | |
| Processo FAPESP: | 06/61311-0 - Avaliação do teste de genotipagem do HIV e terapias de resgate no estado de São Paulo |
| Beneficiário: | Rosangela Rodrigues |
| Modalidade de apoio: | Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS |