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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Young Pregnant Women Living with HIV/AIDS in Criciuma, Southern Brazil, Are Infected Almost Exclusively with HIV Type 1 Clade C

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Author(s):
Rodrigues, Rosangela [1] ; Manenti, Sandra [2] ; Torres Romao, Pedro Roosevelt [3] ; de Paula Ferreira, Joao Leandro [4] ; Gervasio Batista, Joao Paulo [5] ; Almeida Carvalho Siqueira, Antonio Flavio [6] ; de Macedo Brigido, Luis Fernando [7]
Total Authors: 7
Affiliation:
[1] Inst Adolfo Lutz Registro. Retrovirus Lab
[2] Univ Extremo Catarinense. Lab Imunol & Mutagenese
[3] Univ Extremo Catarinense. Lab Imunol & Mutagenese
[4] Inst Adolfo Lutz Registro. Retrovirus Lab
[5] Inst Adolfo Lutz Registro. Retrovirus Lab
[6] Inst Adolfo Lutz Registro. Retrovirus Lab
[7] Inst Adolfo Lutz Registro. Retrovirus Lab
Total Affiliations: 7
Document type: Journal article
Source: AIDS Research and Human Retroviruses; v. 26, n. 3, p. 351-357, MAR 2010.
Web of Science Citations: 12
Abstract

Southern Brazil has the highest prevalence rate of AIDS in the country and is the only region in the Americas where HIV-1 C prevails. Metropolitan areas and harbor cities have been evaluated, but limited information is available for small towns and specific populations. We studied women attending the obstetric outpatient clinic of Criciuma, State of Santa Catarina in 2007 to evaluate the molecular epidemiology of HIV-1 among pregnant women living with HIV/AIDS. Forty-two cases had partial pol gene sequenced and additional partial gag and/or env genes from nine women. HIV subtyping was evaluated by phylogenetic methods and antiretroviral (ARV) drug resistance mutations (DRMs) at the Stanford Database. DRMs to one or more ARV class was observed in 20/42, 48% of cases, with 15/41, 37% with viral load <500 copies/ml. Subtype C at pol was identified in 33/42, 78.6% (95% CI: 64-89%), C mosaics (CB, CF) in 2, 4.8% (95% CI: 0.8-19%), F in 4, 9.5% (95% CI: 3-21%), and B in 3, 7.1% (95% CI: 1.8-18%). Discordance in concatenated gag/pol/env or intraregion mosaic was observed in 1/9, 11% of HIV-1 C genomes. The proportion of HIV-1 C in this study is the highest rate described in the Americas. Molecular surveillance in specific populations is instrumental for a better understanding of the Brazilian HIV epidemic. (AU)

FAPESP's process: 06/61311-0 - HIV genotyping test and of salvage therapies in the state of São Paulo
Grantee:Rosangela Rodrigues
Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)