Decreased CD1a(+), CD83(+) and factor XIIIa(+) dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients

Autor(es)

Gondak, Rogerio ^[1] ; Mauad, Thais ^[2] ; Schultz, Luciana ^[3] ; Soares, Fernando ^[4] ; Kowalski, Luiz P. ^[5] ; Vargas, Pablo A. ^[6]

Afiliação do(s) autor(es)

^[1] Univ Fed Santa Catarina. Dept Pathol

^[2] Univ Sao Paulo. Sch Med

^[3] AC Camargo Hosp. Dept Pathol

^[4] AC Camargo Hosp. Dept Pathol

^[5] AC Camargo Hosp. Dept Head & Neck

^[6] Univ Estadual Campinas. Piracicaba Dent Sch

• Tipo de documento: Artigo Científico
• Fonte: Histopathology; v. 64, n. 2, p. 234-241, JAN 2014.
• Citações Web of Science: 4

Resumo

AimsThe purpose of this study was to quantify and compare the density of dendritic cells (DCs) in cervical lymph nodes (LNs) and palatine tonsils (PTs) of AIDS and non-AIDS patients. Methods and resultsFactor XIIIa, CD1a and CD83 antibodies were used to identify migratory DCs by immunohistochemistry in LNs and PTs of 32 AIDS patients and 21 HIV-negative control patients. Quantification was performed by the positive pixel count analytical method. AIDS patients presented a lower density of factor XIIIa(+) cells (P<0.001), CD1a(+) cells (P<0.05) and CD83(+) cells (P<0.001) in cervical LNs and PTs compared to the non-AIDS control group. ConclusionOverall depletion of DCs in lymphoid tissues of AIDS patients may be predictive of the immune system's loss of disease control. (AU)

• Processo FAPESP: 10/51956-9 - Análise das células dendríticas e sua correlação com as infecções virais e fúngicas diagnosticadas nas línguas, tonsilas palatinas e linfonodos cervicais de pacientes autopsiados com AIDS em estágio avançado
• Beneficiário: Rogério de Oliveira Gondak
• Modalidade de apoio: Bolsas no Brasil - Doutorado