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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Decreased CD1a(+), CD83(+) and factor XIIIa(+) dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients

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Author(s):
Gondak, Rogerio [1] ; Mauad, Thais [2] ; Schultz, Luciana [3] ; Soares, Fernando [4] ; Kowalski, Luiz P. [5] ; Vargas, Pablo A. [6]
Total Authors: 6
Affiliation:
[1] Univ Fed Santa Catarina. Dept Pathol
[2] Univ Sao Paulo. Sch Med
[3] AC Camargo Hosp. Dept Pathol
[4] AC Camargo Hosp. Dept Pathol
[5] AC Camargo Hosp. Dept Head & Neck
[6] Univ Estadual Campinas. Piracicaba Dent Sch
Total Affiliations: 6
Document type: Journal article
Source: Histopathology; v. 64, n. 2, p. 234-241, JAN 2014.
Web of Science Citations: 4
Abstract

AimsThe purpose of this study was to quantify and compare the density of dendritic cells (DCs) in cervical lymph nodes (LNs) and palatine tonsils (PTs) of AIDS and non-AIDS patients. Methods and resultsFactor XIIIa, CD1a and CD83 antibodies were used to identify migratory DCs by immunohistochemistry in LNs and PTs of 32 AIDS patients and 21 HIV-negative control patients. Quantification was performed by the positive pixel count analytical method. AIDS patients presented a lower density of factor XIIIa(+) cells (P<0.001), CD1a(+) cells (P<0.05) and CD83(+) cells (P<0.001) in cervical LNs and PTs compared to the non-AIDS control group. ConclusionOverall depletion of DCs in lymphoid tissues of AIDS patients may be predictive of the immune system's loss of disease control. (AU)