Standardization of Resistance Exercise Training: Effects in Diabetic Ovariectomized Rats

Autor(es)

Sanches, I. C. ^[1] ; Conti, F. F. ^[2] ; Sartori, M. ^[3] ; Irigoyen, M. C. ^[4] ; De Angelis, K. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Nove Julho UNINOVE. Lab Translat Physiol

^[2] Univ Nove Julho UNINOVE. Lab Translat Physiol

^[3] Univ Sao Paulo. Sch Med

^[4] Univ Sao Paulo. Sch Med

^[5] Univ Nove Julho UNINOVE. Lab Translat Physiol

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 35, n. 4, p. 323-329, APR 2014.
• Citações Web of Science: 17

Resumo

This study was carried out with a 3-fold aim: 1) to standardize a maximal load test (MLT) on ladders for prescription of resistance exercise training (RET) in rats, 2) to prescribe moderate-intensity RET based on this MLT and 3) to test the effect of this RET in diabetic ovariectomized rats. Female Wistar rats were divided into control (C), diabetic ovariectomized sedentary (DOS) and trained (DOT) groups. The MLT was standardized with increased load applied to the rat tail for each climb, and blood lactate was measured to identify lactate threshold in C rats. MLT was applied in the 1(st), 4(th) and 8(th) week of the protocol. After 8 weeks of RET, the arterial pressure was directly recorded. DOS group reduced performance in MLT, body weight, left ventricular, plantar and soleus muscles mass (vs. C). DOT rats showed an improvement in MLT associated with plantar muscle mass increased (vs. C and DOS), with attenuation of hypotension and bradycardia (vs. DOS). In conclusion, the results provide a useful method for determining the maximal load and applying RET in rats. Moreover, this study showed that moderate intensity RET improves hemodynamic status in diabetic ovariectomized rats, thereby reinforcing the role of RET in diabetes management. (AU)

• Processo FAPESP: 12/20141-5 - Efeitos do treinamento físico aeróbio, resistido ou combinado em modelos experimentais de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/52419-4 - Papel do estresse oxidativo e do controle autonomico da circulacao na resistencia do miocardio a injuria isquemica no diabete experimental
• Beneficiário: Georgia Orsi Candido
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/57595-5 - Efeitos do treinamento físico no controle autônomo cardiovascular em fêmeas saudáveis e submetidas à privação dos hormônios ovarianos: papel do estresse oxidativo
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores