Population dynamics of genetically diverse Plasmodium falciparum lineages: community-based prospective study in rural Amazonia

Autor(es)

Orjuela-Sanchez, P. ^[1] ; Da Silva-Nunes, M. ^{[1, 2]} ; Da Silva, N. S. ^[1] ; Scopel, K. K. G. ^[1] ; Goncalves, R. M. ^[1] ; Malafronte, R. S. ^{[3, 4]} ; Ferreira, M. U. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508900 Sao Paulo - Brazil

^[2] Univ Fed Acre, Dept Hlth Sci, Rio Branco - Brazil

^[3] Univ Sao Paulo, Inst Trop Med Sao Paulo, Lab Protozool, BR-05508900 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Infect & Parasit Dis, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Parasitology; v. 136, n. 10, p. 1097-1105, SEP 2009.
• Citações Web of Science: 21

Resumo

Temporal changes in the prevalence of antigenic variants in Plasmodium falciparum populations have been interpreted as evidence of immune-mediated frequency-dependent selection, but evolutively neutral processes may generate similar patterns of serotype replacement. Over 4 years, we investigated the population dynamics of P. falciparum polymorphisms the community level by using 11 putatively neutral microsatellite markers. Plasmodium falciparum Populations were less diverse than sympatric P. vivax isolates, with less multiple-clone infections, lower number of alleles per locus and lower Virtual heterozygosity, but both species showed significant multilocus linkage disequilibrium. Evolutively neutral P. falciparum polymorphisms showed a high turnover rate, with few lineages persisting for several months in the population. Similar results had previously been obtained, in the same community, for sympatric P. vivax isolates. In contrast, the prevalence of the 2 dimorphic types of a major antigen, MSP-2, remained remarkably stable throughout the Study period. We Suggest that the relatively fast turnover of parasite lineages represents the typical population dynamics of neutral polymorphisms in small populations, with clear implications for the detection of frequency-dependent selection of polymorphisms. (AU)

• Processo FAPESP: 07/51199-0 - Diversidade genetica, estrutura populacional e dinamica de transmissao de plasmodium vivax na amazonia rural brasileira.
• Beneficiário: Marcelo Urbano Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular