A predictive model of vitamin D insufficiency in older community people: From the Sao Paulo Aging & Health Study (SPAH)

Autor(es)

Lopes, Jaqueline B. ^[1] ; Fernandes, Georgea H. ^[1] ; Takayama, Liliam ^[1] ; Figueiredo, Camille P. ^[1] ; Pereira, Rosa M. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Div Rheumatol, Bone Metab Lab, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MATURITAS; v. 78, n. 4, p. 335-340, AUG 2014.
• Citações Web of Science: 9

Resumo

Objective: To evaluate the prevalence of 25-hydroxyvitamin D insufficiency (25OHD < 20 ng/mL) and to develop a predictive model for this status. Methods: This is a cross-sectional study including 908 community-dwelling older subjects, 18% (158) of which were randomly selected to be a ``test{''} sample, with the remaining (750) composing a ``development{''} sample. A radioimmunoassay technique was used to measure 25OHD levels. Anthropometrical data, information about lifestyle habits and co-morbidities were obtained. Multiple logistic regression models were created. An Index Risk of Vitamin D Insufficiency (IRVDI) was designed and subsequently validated. The performance of this tool was assessed through ROC analysis. Results: The prevalence of 25OHD <20 ng/mL was of 58.0% (CI 95% 51.6-64.6). The clinical independent factors for 25OHD <20 ng/mL were female gender (OR=2.16; 95%CI 1.13-4.13; p=0.020), diabetes (OR=1.84; 95%CI 1.23-2.74; p=0.003) and season (winter/spring) (OR=3.63, 95%CI 2.62-4.88; p < 0.001). After statistical adjustments, the IRVDI was able to identify older people at risk for vitamin D insufficiency with a sensitivity of 55.9%, specificity 72.3% and ROC area of 0.685 (p < 0.001). Conclusions: Our results suggest that vitamin D insufficiency is common among Brazilian community-dwelling elderly. Female gender, diabetes and the season (winter/spring) were the important parameters that predicted this status. The clinical use of these parameters can be help to design and target appropriate public health interventions. The IRVDI is a convenient tool for the selection of older people at risk for vitamin D insufficiency. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 03/09313-0 - Prevalência de osteoporose, fraturas vertebrais e não vertebrais em uma população feminina, de 65 anos ou mais na área do Butantã
• Beneficiário: Rosa Maria Rodrigues Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Regular