S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum

Autor(es)

Steiner, Johann ^{[1, 2]} ; Schmitt, Andrea ^{[3, 4]} ; Schroeter, Matthias L. ^{[5, 6]} ; Bogerts, Bernhard ^{[1, 2]} ; Falkai, Peter ^[4] ; Turck, Christoph W. ^[7] ; Martins-de-Souza, Daniel ^{[3, 7, 4]}

Afiliação do(s) autor(es)

^[1] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg - Germany

^[2] Ctr Behav Brain Sci, Magdeburg - Germany

^[3] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo - Brazil

^[4] Ludwig Maximilians Univ Munich LMU, Dept Psychiat & Psychotherapy, Munich - Germany

^[5] Max Planck Inst Cognit & Human Brain Sci, Leipzig - Germany

^[6] Univ Hosp, Clin Cognit Neurol, Leipzig - Germany

^[7] Max Planck Inst Psychiat, D-80804 Munich - Germany

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE; v. 264, n. 4, p. 311-316, JUN 2014.
• Citações Web of Science: 10

Resumo

Here we report the downregulation of S100B in the nuclear proteome of the corpus callosum from nine schizophrenia patients compared to seven mentally healthy controls. Our data have been obtained primarily by mass spectrometry and later confirmed by Western blot. This is an intriguing finding coming from a brain region which is essentially composed by white matter, considering the potential role of S100B in the control of oligodendrocyte maturation. This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology. (AU)

• Processo FAPESP: 13/08711-3 - Desenvolvimento de um teste preditivo para medicação bem sucedida e compreensão das bases moleculares da esquizofrenia através da proteômica
• Beneficiário: Daniel Martins-de-Souza
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores