The influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patients

Autor(es)

Vicente, Mariana Abe ^[1] ; Silva, Tiago Donizetti ^[1] ; Barao, Katia ^[1] ; Felipe, Aledson Vitor ^[1] ; Missae, Lila Oyama ^[2] ; Forones, Nora Manoukian ^[1]

Afiliação do(s) autor(es)

^[1] Escola Paulista Med, Dept Med, Div Gastroenterol, Oncol Grp, BR-04023 Sao Paulo - Brazil

^[2] Dept Physiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRICION HOSPITALARIA; v. 30, n. 1, p. 140-146, JUL 2014.
• Citações Web of Science: 3

Resumo

Background: The aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-a (TNF-alpha) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status. Methods: A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-alpha serum concentrations were determined using an enzyme-linked immunosorbent assay. Results: Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-alpha serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-alpha than those with lower stage disease (p = 0.037). The three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF-alpha, when distributed PhA in tertiles. Conclusions: Adiponectin levels were higher among CRC patients. Although TNF-alpha serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-alpha, when distributed PhA in tertiles. (AU)

• Processo FAPESP: 10/19191-2 - Análise da eficácia de métodos e indicadores de estado nutricional em pacientes com câncer de esôfago, gástrico e colorretal
• Beneficiário: Nora Manoukian Forones
• Modalidade de apoio: Auxílio à Pesquisa - Regular