| Full text | |
| Author(s): |
Vicente, Mariana Abe
[1]
;
Silva, Tiago Donizetti
[1]
;
Barao, Katia
[1]
;
Felipe, Aledson Vitor
[1]
;
Missae, Lila Oyama
[2]
;
Forones, Nora Manoukian
[1]
Total Authors: 6
|
| Affiliation: | [1] Escola Paulista Med, Dept Med, Div Gastroenterol, Oncol Grp, BR-04023 Sao Paulo - Brazil
[2] Dept Physiol, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | NUTRICION HOSPITALARIA; v. 30, n. 1, p. 140-146, JUL 2014. |
| Web of Science Citations: | 3 |
| Abstract | |
Background: The aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-a (TNF-alpha) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status. Methods: A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-alpha serum concentrations were determined using an enzyme-linked immunosorbent assay. Results: Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-alpha serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-alpha than those with lower stage disease (p = 0.037). The three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF-alpha, when distributed PhA in tertiles. Conclusions: Adiponectin levels were higher among CRC patients. Although TNF-alpha serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-alpha, when distributed PhA in tertiles. (AU) | |
| FAPESP's process: | 10/19191-2 - Analysis of the effectiveness of methods and indicators of nutritional status pertaining to patients with esophageal, gastric and colorectal cancer |
| Grantee: | Nora Manoukian Forones |
| Support Opportunities: | Regular Research Grants |