[6]-gingerol as a Cancer Chemopreventive Agent: A Review of Its Activity on Different Steps of the Metastatic Process

Autor(es)

Poltronieri, Juliana ^[1] ; Becceneri, Amanda B. ^[1] ; Fuzer, Angelina M. ^[1] ; Cesar C. Filho, Julio ^[1] ; Martin, Ana Carolina B. M. ^[2] ; Vieira, Paulo Cezar ^[3] ; Pouliot, Normand ^{[4, 5, 6]} ; Cominetti, Marcia R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Gerontol, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Ciencias Fisiol, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[4] Peter MacCallum Canc Ctr, Metastasis Res Lab, Melbourne, Vic - Australia

^[5] Univ Melbourne, Sir Peter MacCallum Dept, Melbourne, Vic - Australia

^[6] Univ Melbourne, Dept Pathol & Oncol, Melbourne, Vic - Australia

• Tipo de documento: Artigo de Revisão
• Fonte: MINI-REVIEWS IN MEDICINAL CHEMISTRY; v. 14, n. 4, p. 313-321, 2014.
• Citações Web of Science: 19

Resumo

For many years, ginger or ginger root, the rhizome of the plant Zingiber officinale, has been consumed as a delicacy, medicine, or spice. Several studies have been conducted on the medicinal properties of ginger against various disorders, including cancer. Cancer is the second leading cause of death, and chemoprevention is defined as the use of natural or synthetic substances to prevent cancer initiation or progression. Evidence that ginger-derived compounds have inhibitory effects on various cancer cell types is increasingly being reported in the scientific literature. In this review we focused on the cancer chemopreventive effects of {[}6]-gingerol, the major pungent component of ginger, and its impact on different steps of the metastatic process. (AU)

• Processo FAPESP: 08/56758-0 - Triagem em larga escala de produtos de origem natural com atividade antitumoral em cultura de células de mamífero
• Beneficiário: Márcia Regina Cominetti
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores