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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Periodontal disease in pediatric rheumatic diseases

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Autor(es):
Fabri, Gisele M. C. [1, 2] ; Savioli, Cynthia [1] ; Siqueira, Jose T. [1] ; Campos, Lucia M. [3] ; Bonfa, Eloisa [4] ; Silva, Clovis A. [3, 4]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Dent Div, Sao Paulo - Brazil
[2] Univ Fed Juiz de Fora, Fac Odontol, Juiz De Fora, MG - Brazil
[3] Univ Sao Paulo, Fac Med, Paediat Rheumatol Unit, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Rheumatol Div, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: Revista Brasileira de Reumatologia; v. 54, n. 4, p. 311-317, JUL-AUG 2014.
Citações Web of Science: 3
Resumo

Gingivitis and periodontitis are immunoinflammatory periodontal diseases characterized by chronic localized infections usually associated with insidious inflammation. This narrative review discusses periodontal diseases and mechanisms influencing the immune response and autoimmunity in pediatric rheumatic diseases (PRD), particularly juvenile idiopathic arthritis (JIA), childhood-onset systemic lupus erythematosus (C-SLE) and juvenile dermatomyositis (JDM). Gingivitis was more frequently observed in these diseases compared to health controls, whereas periodontitis was a rare finding. In JIA patients, gingivitis and periodontitis were related to mechanical factors, chronic arthritis with functional disability, dysregulation of the immunoinflammatory response, diet and drugs, mainly corticosteroids and cyclosporine. In C-SLE, gingivitis was associated with longer disease period, high doses of corticosteroids, B-cell hyperactivation and immunoglobulin G elevation. There are scarce data on periodontal diseases in JDM population, and a unique gingival pattern, characterized by gingival erythema, capillary dilation and bush-loop formation, was observed in active patients. In conclusion, gingivitis was the most common periodontal disease in PRD. The observed association with disease activity reinforces the need for future studies to determine if resolution of this complication will influence disease course or severity. (C) 2014 Sociedade Brasileira de Reumatologia. Published by Elsevier Editora Ltda. All rights reserved. (AU)

Processo FAPESP: 10/12035-5 - Terapia anti-TNF em doenças auto-imunes reumatológicas: abordagem de aspectos peculiares
Beneficiário:Gisele Maria Campos Fabri
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 09/51897-5 - Terapia anti-TNF em doenças auto-imunes reumatológicas: abordagem de aspectos peculiares
Beneficiário:Eloisa Silva Dutra de Oliveira Bonfá
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 08/58238-4 - Autoimunidade na criança: investigação das bases moleculares e celulares da autoimunidade de início precoce
Beneficiário:Magda Maria Sales Carneiro-Sampaio
Linha de fomento: Auxílio à Pesquisa - Temático