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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Periodontal disease in pediatric rheumatic diseases

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Author(s):
Fabri, Gisele M. C. [1, 2] ; Savioli, Cynthia [1] ; Siqueira, Jose T. [1] ; Campos, Lucia M. [3] ; Bonfa, Eloisa [4] ; Silva, Clovis A. [3, 4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Med, Dent Div, Sao Paulo - Brazil
[2] Univ Fed Juiz de Fora, Fac Odontol, Juiz De Fora, MG - Brazil
[3] Univ Sao Paulo, Fac Med, Paediat Rheumatol Unit, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Rheumatol Div, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Review article
Source: Revista Brasileira de Reumatologia; v. 54, n. 4, p. 311-317, JUL-AUG 2014.
Web of Science Citations: 3
Abstract

Gingivitis and periodontitis are immunoinflammatory periodontal diseases characterized by chronic localized infections usually associated with insidious inflammation. This narrative review discusses periodontal diseases and mechanisms influencing the immune response and autoimmunity in pediatric rheumatic diseases (PRD), particularly juvenile idiopathic arthritis (JIA), childhood-onset systemic lupus erythematosus (C-SLE) and juvenile dermatomyositis (JDM). Gingivitis was more frequently observed in these diseases compared to health controls, whereas periodontitis was a rare finding. In JIA patients, gingivitis and periodontitis were related to mechanical factors, chronic arthritis with functional disability, dysregulation of the immunoinflammatory response, diet and drugs, mainly corticosteroids and cyclosporine. In C-SLE, gingivitis was associated with longer disease period, high doses of corticosteroids, B-cell hyperactivation and immunoglobulin G elevation. There are scarce data on periodontal diseases in JDM population, and a unique gingival pattern, characterized by gingival erythema, capillary dilation and bush-loop formation, was observed in active patients. In conclusion, gingivitis was the most common periodontal disease in PRD. The observed association with disease activity reinforces the need for future studies to determine if resolution of this complication will influence disease course or severity. (C) 2014 Sociedade Brasileira de Reumatologia. Published by Elsevier Editora Ltda. All rights reserved. (AU)

FAPESP's process: 08/58238-4 - Autoimmunity in children: investigation of the molecular and cellular bases of early onset of autoimmunity
Grantee:Magda Maria Sales Carneiro-Sampaio
Support Opportunities: Research Projects - Thematic Grants