Dynamic aerobic exercise induces baroreflex improvement in diabetic rats

• Processo: 11/21797-9
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo
• Data de Início da vigência: 01 de janeiro de 2012
• Data de Término da vigência: 30 de junho de 2012
• Área do conhecimento: Ciências Biológicas - Fisiologia - Fisiologia de Órgãos e Sistemas
• Pesquisador responsável: Kátia de Angelis Lobo D Avila
• Beneficiário: Kátia de Angelis Lobo D Avila
• Instituição Sede: Universidade Nove de Julho (UNINOVE). Campus Memorial. São Paulo , SP, Brasil
• Município da Instituição Sede: São Paulo
• Assunto(s): Diabetes mellitus experimental Doenças cardiovasculares Treinamento aeróbio Pressão sanguínea Frequência cardíaca Barorreflexo Publicações de divulgação científica Artigo científico
• Palavra(s)-Chave do Pesquisador: acute exercise | baroreflex | experimental diabetes | Fisiologia Cardiovascular

Resumo

The objective of the present study was to investigate the effects of an acute aerobic exercise on arterial pressure (AP), heart rate (HR) and baroreflex sensitivity (BRS) in STZ-induced diabetic rats. Male Wistar rats were divided into: control (n=8) and diabetic (n=8) groups. AP, HR and BRS, which was measured by tachycardic and bradycardic (BR) responses to AP changes, were evaluated at rest (R) and postexercise session (PE) on a treadmill. At rest, STZ diabetes induced AP and HR reductions, associated with BR impairment. Attenuation in resting diabetes-induced AP (R: 103±2 vs. PE: 111±3 mmHg) and HR (R: 290±7 vs. PE: 328±10 bpm) reductions and BR dysfunction (R: -0.70±0.06 vs. PE: -1.21±0.09 bpm/mmHg) were observed in the postexercise period. In conclusion, the hemodynamic and arterial baro-mediated control of circulation improvement in the postexercise period reinforces the role of exercise in the management of cardiovascular risk in diabetes. (AU)