Dynamic aerobic exercise induces baroreflex improvement in diabetic rats

• Grant number: 11/21797-9
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: January 01, 2012
• End date: June 30, 2012
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Kátia de Angelis Lobo D Avila
• Grantee: Kátia de Angelis Lobo D Avila
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Memorial. São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

The objective of the present study was to investigate the effects of an acute aerobic exercise on arterial pressure (AP), heart rate (HR) and baroreflex sensitivity (BRS) in STZ-induced diabetic rats. Male Wistar rats were divided into: control (n=8) and diabetic (n=8) groups. AP, HR and BRS, which was measured by tachycardic and bradycardic (BR) responses to AP changes, were evaluated at rest (R) and post exercise session (PE) on a treadmill. At rest, STZ diabetes induced AP and HR reductions, associated with BR impairment. Attenuation in resting diabetes-induced AP (R: 103±2 vs. PE: 111±3 mmHg) and HR (R: 290±7 vs. PE: 328±10 bpm) reductions and BR dysfunction (R: -0.70±0.06 vs. PE: -1.21±0.09 bpm/mmHg) were observed in the post exercise period. In conclusion, the hemodynamic and arterial baro-mediated control of circulation improvement in the post exercise period reinforces the role of exercise in the management of cardiovascular risk in diabetes. (AU)