Interaction between the antimicrobial peptide Aurein 1.2 dimer and mannans

Autor(es)

Lorenzon, Esteban N. ^[1] ; Piccoli, Julia P. ^[1] ; Cilli, Eduardo M. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Inst Chem, BR-14800060 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Amino Acids; v. 46, n. 11, p. 2627-2631, NOV 2014.
• Citações Web of Science: 8

Resumo

We have previously described the structure and the ability of a dimeric analog of the antimicrobial peptide Aurein 1.2 to aggregate Candida albicans. In this study, circular dichroism and fluorescence spectroscopy data showed that this aggregation is related to the interaction between the peptide and mannans, the main component of yeast cell wall. In this context, we propose a model in which dimers interact with the polysaccharide leading to cells aggregation. (AU)

• Processo FAPESP: 12/15346-7 - Peptídeos antimicrobianos: efeito da dimerização e produção de biomembranas de látex/peptídeos
• Beneficiário: Eduardo Maffud Cilli
• Modalidade de apoio: Auxílio à Pesquisa - Regular