The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies

Autor(es)

Ferreira, Luiz K. ^{[1, 2]} ; Tamashiro-Duran, Jaqueline H. ^{[1, 2]} ; Squarzoni, Paula ^{[1, 2]} ; Duran, Fabio L. ^{[1, 2]} ; Alves, Tania C. ^{[1, 2]} ; Buchpiguel, Carlos A. ^{[2, 3]} ; Busatto, Geraldo F. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Lab Psychiat Neuroimaging LIM 21, BR-09500900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-09500900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Radiol, Nucl Med Div LIM 43, BR-09500900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Revista Brasileira de Psiquiatria; v. 36, n. 4, p. 344-357, OCT-DEC 2014.
• Citações Web of Science: 4

Resumo

Objective: To review functional neuroimaging studies about the relationship between cardiovascular risk factors (CVRFs), Alzheimer's disease (AD), and mild cognitive impairment (MCI). Methods: We performed a comprehensive literature search to identify articles in the neuroimaging field addressing CVRF in AD and MCI. We included studies that used positron emission tomography (PET), single photon emission computerized tomography (SPECT), or functional magnetic resonance imaging (fMRI). Results: CVRFs have been considered risk factors for cognitive decline, MCI, and AD. Patterns of AD-like changes in brain function have been found in association with several CVRFs (both regarding individual risk factors and also composite CVRF measures). In vivo assessment of AD-related pathology with amyloid imaging techniques provided further evidence linking CVRFs and AD, but there is still limited information resulting from this new technology. Conclusion: There is a large body of evidence from functional neuroimaging studies supporting the hypothesis that CVRFs may play a causal role in the pathophysiology of AD. A major limitation of most studies is their cross-sectional design; future longitudinal studies using multiple imaging modalities are expected to better document changes in CVRF-related brain function patterns and provide a clearer picture of the complex relationship between aging, CVRFs, and AD. (AU)

• Processo FAPESP: 12/50329-6 - Neurociência translacional da doença de Alzheimer: estudos pré-clínicos e clínicos do peptídeo b-amiloide e outros biomarcadores
• Beneficiário: Geraldo Busatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/11898-5 - Aplicação do método partial least squares para análise de ressonância magnética funcional de repouso: estudo sobre envelhecimento cerebral e memória autobiográfica
• Beneficiário: Luiz Roberto Kobuti Ferreira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto