Trentin, Danielle S.
Silva, Denise B.
Frasson, Amanda P.
da Silva, Marcia V.
Pulcini, Elinor de L.
Soares, Gabriel V.
Giordani, Raquel B.
Lopes, Norberto P.
Macedo, Alexandre J.
Número total de Autores: 13
Afiliação do(s) autor(es):
 Univ Fed Rio Grande do Sul, Fac Farm, BR-90610000 Porto Alegre, RS - Brazil
 Univ Fed Rio Grande do Sul, Ctr Biotecnol, BR-91501970 Porto Alegre, RS - Brazil
 Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisas Prod Nat & Sintet NPPNS, BR-14040903 Ribeirao Preto, SP - Brazil
 Umea Univ, Dept Chem, SE-90187 Umea - Sweden
 Univ Fed Pernambuco, Dept Bioquim, BR-50670901 Recife, PE - Brazil
 Univ Fed Pernambuco, Ctr Ciencias Biol, BR-50670901 Recife, PE - Brazil
 Montana State Univ, Ctr Biofilm Engn, Bozeman, MT 59717 - USA
 Univ Fed Rio Grande do Sul, Inst Fis, BR-91509900 Porto Alegre, RS - Brazil
 Univ Fed Rio Grande do Norte, Ctr Ciencias Saude, Dept Farm, BR-59010180 Natal, RN - Brazil
Número total de Afiliações: 9
Tipo de documento:
FEB 6 2015.
Citações Web of Science:
Despite many advances, biomaterial-associated infections continue to be a major clinical problem. In order to minimize bacterial adhesion, material surface modifications are currently being investigated and natural products possess large potential for the design of innovative surface coatings. We report the bioguided phytochemical investigation of Pityrocarpa moniliformis and the characterization of tannins by mass spectrometry. It was demonstrated that B-type linked proanthocyanidins-coated surfaces, here termed Green coatings, reduced Gram-positive bacterial adhesion and supported mammalian cell spreading. The proposed mechanism of bacterial attachment inhibition is based on electrostatic repulsion, high hydrophilicity and the steric hindrance provided by the coating that blocks bacterium-substratum interactions. This work shows the applicability of a prototype Green-coated surface that aims to promote necessary mammalian tissue compatibility, while reducing bacterial colonization. (AU)