Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis

Autor(es)

Furtado, Ricardo A. ^[1] ; Oliveira, Barthira R. ^[1] ; Silva, Luciana R. ^[1] ; Cleto, Sabrina S. ^[1] ; Munari, Carla C. ^[1] ; Cunha, Wilson R. ^[1] ; Tavares, Denise C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, BR-14404600 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Cancer Prevention; v. 24, n. 2, p. 106-112, MAR 2015.
• Citações Web of Science: 16

Resumo

Rosmarinic acid (RA) is a polyphenolic compound that shows a number of interesting biological activities, such as antiapoptotic, antifibrotic, antioxidant, hepatoprotective, antineurodegenerative, and anti-inflammatory properties. The aim of this study was to investigate the ability of RA to prevent 1,2-dimethylhydrazine (DMH)-induced primary DNA damage and aberrant crypt foci (ACF) in Wistar rat colon. The animals were treated by gavage with doses of 4, 8, and 16 mg/kg body weight/day. Next, the animals received a single subcutaneous injection of 40 mg/kg DMH and were killed 4 h later for the evaluation of DNA damage using the comet assay. In addition, two doses of 40 mg/kg DMH were administered weekly for 2 weeks and the animals were killed 2 weeks after the last injection for the evaluation of ACF formation in rat colon. The results showed that RA exerted no genotoxic/carcinogenic effects. Treatment with different doses of RA combined with DMH led to a significant reduction in the extent of DNA damage and in the frequency of ACF compared with animals treated with DMH alone. These findings suggest that RA reduces DNA damage and suppresses the formation of ACF. European Journal of Cancer Prevention 24: 106-112 Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. (AU)

• Processo FAPESP: 08/02211-0 - Avaliação do efeito do ácido rosmarínico sobre os danos de dna em células de mamíferos in vivo e in vitro e sobre a carcinogênese de cólon de ratos
• Beneficiário: Ricardo Andrade Furtado
• Modalidade de apoio: Bolsas no Brasil - Mestrado