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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis

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Author(s):
Furtado, Ricardo A. [1] ; Oliveira, Barthira R. [1] ; Silva, Luciana R. [1] ; Cleto, Sabrina S. [1] ; Munari, Carla C. [1] ; Cunha, Wilson R. [1] ; Tavares, Denise C. [1]
Total Authors: 7
Affiliation:
[1] Univ Franca, BR-14404600 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: European Journal of Cancer Prevention; v. 24, n. 2, p. 106-112, MAR 2015.
Web of Science Citations: 16
Abstract

Rosmarinic acid (RA) is a polyphenolic compound that shows a number of interesting biological activities, such as antiapoptotic, antifibrotic, antioxidant, hepatoprotective, antineurodegenerative, and anti-inflammatory properties. The aim of this study was to investigate the ability of RA to prevent 1,2-dimethylhydrazine (DMH)-induced primary DNA damage and aberrant crypt foci (ACF) in Wistar rat colon. The animals were treated by gavage with doses of 4, 8, and 16 mg/kg body weight/day. Next, the animals received a single subcutaneous injection of 40 mg/kg DMH and were killed 4 h later for the evaluation of DNA damage using the comet assay. In addition, two doses of 40 mg/kg DMH were administered weekly for 2 weeks and the animals were killed 2 weeks after the last injection for the evaluation of ACF formation in rat colon. The results showed that RA exerted no genotoxic/carcinogenic effects. Treatment with different doses of RA combined with DMH led to a significant reduction in the extent of DNA damage and in the frequency of ACF compared with animals treated with DMH alone. These findings suggest that RA reduces DNA damage and suppresses the formation of ACF. European Journal of Cancer Prevention 24: 106-112 Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. (AU)

FAPESP's process: 08/02211-0 - Evaluation of rosmarinic acid effect on DNA damage in in vivo and in vitro mammalian cells and on rats colon carcinogenesis
Grantee:Ricardo Andrade Furtado
Support type: Scholarships in Brazil - Master